Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0308258
PubChem CID
Molecular Formula
C8H5N3O
Molecular Weight
159.148 g/mol
Synonyms/Alias
InChI Key
NBCMHCSMMPJOBH-UHFFFAOYSA-N
InChI
InChI=1S/C8H5N3O/c9-4-5-7-6(11-8(5)12)2-1-3-10-7/h1-3,10H,(H,11,12)
IUPAC Name
2-oxo-1,4-dihydropyrrolo[3,2-b]pyridine-3-carbonitrile
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

12 13 0 0 0 0 0 0 0 0999 V2000
-3.3147 0.1620 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.6566 1.5099 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.1602 1...

Experimental Data

Activity Data

Target Ion Channel
Calcium activated potassium channel subunit alpha-1
Uniprot Accession Number
Function
Opener
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
EC50: 13400 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
Not specified
Temperature
37 °C
Test Method
Efflux Assay ([86] Rubidium Ion)
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
12
Rotatable Bonds
0
logP
0.6795
Complexity
42.7504
TPSA (Ų)
72.44
H-Bond Donors
2
H-Bond Acceptors
2
Ring Count
2
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